Melanotan-2 10mg — Melanocortin Receptor Agonist Research Peptide
Melanotan-2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), one of the body’s naturally occurring melanocortin peptides. First synthesized at the University of Arizona in the 1980s as part of a research program into skin pigmentation and sun protection, Melanotan-2 has since become one of the most studied melanocortin receptor agonists in peptide research — with documented effects spanning skin pigmentation, libido and sexual function, appetite modulation, and energy metabolism.
H&J Pharma supplies Melanotan-2 10mg at HPLC-verified ≥99% purity for qualified research applications.
Product Overview
Melanotan-2 is a cyclic heptapeptide analogue of α-MSH that acts as a non-selective agonist of melanocortin receptors MC1R, MC3R, MC4R, and MC5R. This broad receptor binding profile underlies its diverse range of studied effects: MC1R activation drives melanogenesis (skin tanning); MC4R activation influences sexual arousal and appetite suppression; MC3R and MC5R activation contributes to energy balance and exocrine function.
The wide range of biological effects associated with Melanotan-2 has made it a subject of ongoing research in dermatology, sexual medicine, appetite neuroscience, and metabolic health.
Key Benefits
- Skin pigmentation research — activates MC1R to stimulate melanogenesis and tanning response
- Libido and sexual function — MC4R agonism studied for its role in sexual arousal pathways
- Appetite modulation — MC4R activation associated with reduced caloric intake in research models
- Energy metabolism effects — studied for its influence on energy balance and fat metabolism
- Erectile function research — documented effects on penile erection via MC4R/neural pathways
- Skin protection research — original research context was photoprotection via induced tanning
- Broad melanocortin receptor activity — non-selective MC receptor agonism with multi-system effects
Popular Use Cases
Melanotan-2 research is distributed across several areas. Dermatological researchers study its tanning and photoprotective properties via MC1R activation. Sexual medicine researchers study its MC4R-mediated effects on libido and erectile function — PT-141 (Bremelanotide) was derived directly from Melanotan-2 research. Metabolic researchers explore its appetite-suppressive and energy-regulating properties via central MC4R signaling.
Who Commonly Uses This
Melanotan-2 draws interest from dermatology researchers, sexual medicine scientists, neuroscientists studying melanocortin receptor systems, and metabolic health researchers. Wellness-oriented individuals interested in skin tanning biology and body composition research also follow MT-2 literature closely.
Product Details
| Peptide | Melanotan-2 (α-MSH analogue) |
| Content | 10mg per vial |
| Format | Lyophilized powder |
| BAC Water | Included |
| Purity | ≥99% HPLC verified |
| Storage (lyophilized) | 2–8°C, away from light |
| Storage (reconstituted) | 2–8°C, use within 30 days |
| Research Use | For laboratory and research purposes only |
Storage & Handling
Store lyophilized Melanotan-2 at 2–8°C protected from light. Once reconstituted, store refrigerated and use within 28–30 days. Avoid vigorous shaking and repeated freeze-thaw cycles.
Research & Scientific Interest
Melanotan-2 research has generated significant scientific literature spanning skin biology, sexual medicine, and neuroscience. The peptide’s role in melanocortin receptor pharmacology has directly influenced the development of approved medications including PT-141 (Bremelanotide/Vyleesi) for sexual dysfunction. Its MC4R agonism continues to be investigated in obesity research, and its skin protection properties remain an active area in photodermatology.
Frequently Asked Questions
Melanotan-2 is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). It activates melanocortin receptors (MC1R, MC3R, MC4R, MC5R) and is researched for skin pigmentation, sexual function, appetite modulation, and energy metabolism.
MT-2 is a non-selective melanocortin receptor agonist acting on MC1R (skin pigmentation), MC3R and MC4R (appetite, energy balance, sexual function), and MC5R (exocrine functions). This broad receptor activity underlies its diverse studied effects.
PT-141 (Bremelanotide) was developed from Melanotan-2 research. PT-141 is a more selective analogue focused on MC4R activation for sexual function, derived from the same melanocortin receptor agonist research program.
Yes. Each vial includes bacteriostatic water for reconstitution.
Store lyophilized at 2–8°C away from light. Once reconstituted, refrigerate and use within 28–30 days.
No. This product is sold strictly for laboratory and research purposes only. Not approved for human consumption or therapeutic use.
≥99% purity as verified by HPLC.
Yes. H&J Pharma offers same-day shipping with next-day delivery across Vietnam.
Research References
- Dorr RT, et al. “Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.” Life Sciences. 1996. PubMed
- Wessells H, et al. “Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction.” Journal of Urology. 1998. PubMed
- Hadley ME. “Discovery that a melanocortin regulates sexual functions in male and female humans.” Peptides. 2005. PubMed
- Catania A, et al. “The melanocortin system in control of inflammation.” Science Signaling. 2004.
- Adan RA, et al. “Melanocortin receptors mediate alpha-MSH-induced stimulation of neurite outgrowth.” Molecular Pharmacology. 1999.
- Barsh GS. “From agouti to pomc — 100 years of fat blonde mice.” Nature Medicine. 1999. PubMed
- Cone RD. “Anatomy and regulation of the central melanocortin system.” Nature Neuroscience. 2005. PubMed
- Gantz I, et al. “Molecular cloning of a novel melanocortin receptor.” Journal of Biological Chemistry. 1993. PubMed
- Wikberg JE. “Melanocortin receptors: perspectives for novel drugs.” European Journal of Pharmacology. 1999. PubMed
- King SH, et al. “Melanocortin MC4 receptor agonism facilitates penile erection.” European Journal of Pharmacology. 2007. PubMed
Lifestyle & Wellness Context
Melanotan-2 occupies a unique position in peptide research — its origins in sun protection science evolved into one of the most interesting multi-system receptor agonist studies in modern pharmacology. Its legacy continues in PT-141 (Bremelanotide), the FDA-approved medication for female sexual dysfunction derived directly from MT-2 research. H&J Pharma supplies Melanotan-2 at research grade with HPLC-verified purity and same-day shipping across Vietnam.
Related Wellness Research Areas
Research communities studying melanocortin biology, skin pigmentation science, sexual medicine, appetite neuroscience, energy metabolism, and receptor pharmacology will find Melanotan-2 a richly documented subject with broad translational relevance.
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