Semax 10mg — Neuropeptide for Cognitive Research & Neuroprotection
Semax is a synthetic heptapeptide analogue of ACTH(4-10) developed by the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s. Unlike many peptides that target peripheral tissue, Semax operates primarily within the central nervous system — where it has been studied extensively for its nootropic, neuroprotective, anxiolytic, and cognitive-enhancing properties.
H&J Pharma supplies Semax 10mg at HPLC-verified ≥99% purity for researchers studying CNS peptide pharmacology, cognitive function, and neuroprotection mechanisms.
Product Overview
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a heptapeptide derived from the adrenocorticotropic hormone (ACTH) fragment 4-7, with added proline-glycine-proline (PGP) sequence for enhanced stability. It has been used clinically in Russia since 1996 for stroke recovery, cognitive impairment, and neurodegenerative conditions — representing one of the few research peptides with a documented clinical history in a national healthcare system.
Key mechanisms include upregulation of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and other neurotrophins; modulation of dopamine, serotonin, and enkephalin systems; anti-inflammatory activity within the CNS; and neuroprotective effects against oxidative stress and ischemic damage.
Key Benefits
- BDNF and NGF upregulation — promotes neurotrophin production supporting neural plasticity
- Cognitive enhancement research — studied for improvements in memory, attention, and learning
- Neuroprotective effects — protects neurons from ischemic damage and oxidative stress
- Anxiolytic properties — modulates HPA axis to reduce stress responses in research models
- Dopamine and serotonin modulation — influences key neurotransmitter systems
- Anti-inflammatory CNS activity — reduces neuroinflammation in preclinical studies
- Stroke recovery research — clinical use in Russia for post-stroke rehabilitation
- Focus and mental clarity — studied for its effects on executive function and concentration
Popular Use Cases
Semax research spans neuroscience, cognitive medicine, and longevity science. Its documented BDNF and NGF upregulation makes it particularly interesting for researchers studying neuroplasticity, learning enhancement, and neurodegenerative disease prevention. The biohacking community has shown significant interest in Semax as a nootropic for cognitive performance optimization.
Who Commonly Uses This
Semax attracts researchers in neuroscience, cognitive medicine, and longevity science. Biohackers and cognitive performance researchers, practitioners studying stroke recovery, and scientists exploring neuroprotection and neurotrophin regulation represent the primary research populations.
Product Details
| Peptide | Semax (ACTH(4-10) analogue) |
| Content | 10mg per vial |
| Format | Lyophilized powder |
| BAC Water | Included |
| Purity | ≥99% HPLC verified |
| Storage (lyophilized) | 2–8°C, away from light |
| Storage (reconstituted) | 2–8°C, use within 30 days |
| Research Use | For laboratory and research purposes only |
Storage & Handling
Store lyophilized Semax at 2–8°C protected from light. Once reconstituted, refrigerate and use within 28–30 days. Avoid vigorous shaking and repeated freeze-thaw cycles.
Research & Scientific Interest
Semax represents the intersection of neuropeptide pharmacology and practical clinical application. Its documented upregulation of BDNF — one of the key neurotrophins supporting neural survival and plasticity — has established it as one of the most studied cognitive enhancement peptides. Russian clinical use since 1996 provides a unique translational context rarely seen in research peptides.
Frequently Asked Questions
Semax is a synthetic heptapeptide analogue of ACTH(4-10) developed in Russia. It upregulates BDNF and NGF, modulates neurotransmitter systems, and is studied for cognitive enhancement, neuroprotection, anxiolytic effects, and stroke recovery.
Semax is one of the few research peptides with clinical use history — approved and used in Russia since 1996 for stroke rehabilitation and cognitive conditions. Its BDNF and NGF upregulation distinguishes it as one of the most studied neurotrophin-activating peptides.
Studies show Semax significantly upregulates BDNF (brain-derived neurotrophic factor) in the hippocampus and cortex. BDNF is essential for neural plasticity, memory consolidation, and neuronal survival — making Semax highly relevant to cognitive and neuroprotection research.
In research settings, Semax is frequently referenced alongside Selank for complementary nootropic and anxiolytic effects. Research protocols should be designed by qualified researchers familiar with each peptide’s mechanisms.
Yes. Each vial includes bacteriostatic water for reconstitution.
Store lyophilized at 2–8°C away from light. Once reconstituted, refrigerate and use within 28–30 days.
No. This product is sold strictly for laboratory and research purposes only.
Yes. H&J Pharma offers same-day shipping with next-day delivery across Vietnam.
Research References
- Limborska SA, et al. “Analysis of Semax activity in the human memory and attention.” Molecular Biology. 2002.
- Shadrina MI, et al. “Expression analysis of neuroprotective effect of Semax.” Journal of Molecular Neuroscience. 2010. PubMed
- Dolotov OV, et al. “Semax stimulates BDNF expression in the rat hippocampus.” Cellular and Molecular Neurobiology. 2006. PubMed
- Mjasoedov NF, et al. “Analysis of Semax action on the serum of patients with ischemic stroke.” Russian Journal of Bioorganic Chemistry. 1999.
- Inozemtseva LS, et al. “Intranasal administration of Semax affect the expression of genes related to the dopamine system.” Russian Journal of Genetics. 2007.
- Agapova TY, et al. “Effect of ACTH4-7 Pro-Gly-Pro on actin cytoskeleton and cell migration.” Neuroscience Letters. 2007. PubMed
- Kolomin T, et al. “A new generation of drugs: synthetic peptides based on natural regulatory peptides.” Neuroscience and Medicine. 2013.
- Gusev EI, et al. “Semax in the treatment of patients in the acute period of hemispheric ischemic stroke.” Journal of Neurology and Psychiatry. 2005.
- Grigoreva ME, et al. “Antistress effects of Semax during immobilization stress in rats.” Bulletin of Experimental Biology and Medicine. 2009.
- Filatova EV, et al. “Semax and selank inhibit the enkephalin-degrading enzymes from human serum.” Biochemistry. 2012. PubMed
Lifestyle & Wellness Context
Semax stands at the frontier of cognitive wellness research — a neuropeptide with both robust preclinical data and real clinical application history. For researchers studying the biology of cognition, neuroprotection, and healthy brain aging, Semax offers a uniquely documented research subject. H&J Pharma supplies Semax 10mg at research grade with same-day shipping across Vietnam.
Related Wellness Research Areas
Research communities studying cognitive enhancement, BDNF biology, neuroprotection, neuroplasticity, stroke recovery, anxiety neuroscience, and CNS longevity will find Semax one of the most thoroughly referenced neuropeptides in modern cognitive science.
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