MOTS-C 20mg — Mitochondrial-Derived Peptide for Metabolic & Longevity Research
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a groundbreaking mitochondria-derived peptide that has rapidly emerged as one of the most exciting subjects in longevity and metabolic health research. First characterized in 2015 by researchers at USC’s Davis School of Gerontology, MOTS-C is encoded in the mitochondrial genome — making it unique among research peptides — and has been studied for its remarkable effects on metabolic regulation, insulin sensitivity, exercise capacity, and healthy aging.
Product Overview
MOTS-C is a 16-amino acid peptide encoded within the 12S ribosomal RNA gene of the mitochondrial genome. Upon cellular stress, MOTS-C translocates from the mitochondria to the nucleus, where it regulates gene expression related to metabolic adaptation, antioxidant response, and longevity pathways. Its primary mechanism involves activation of AMPK (AMP-activated protein kinase) — the master energy sensing enzyme — making it highly relevant to researchers studying metabolic flexibility, cellular energy regulation, and age-related metabolic decline.
Key Benefits
- AMPK pathway activation — enhances cellular energy sensing and metabolic flexibility
- Insulin sensitivity improvement — studied for its effects on glucose uptake and insulin resistance
- Exercise performance research — MOTS-C levels increase during exercise; supplemental research explores performance implications
- Mitochondrial health — unique mitochondria-derived mechanism supports cellular energy optimization
- Anti-aging mechanisms — studied for its role in longevity pathways and age-related metabolic decline
- Antioxidant defense — activates Nrf2 pathway and antioxidant gene expression
- Body composition research — reduces high-fat diet-induced obesity in preclinical models
- Bone health research — emerging evidence for osteoblast activation and bone loss prevention
Popular Use Cases
MOTS-C is studied in longevity research, metabolic health science, exercise physiology, and anti-aging medicine. Its unique mitochondrial origin and AMPK activation mechanism make it particularly relevant to researchers studying the biology of cellular energy regulation, metabolic syndrome, insulin resistance, and age-related decline. The peptide has also attracted attention in sports science given its relationship to exercise-induced metabolic adaptation.
Who Commonly Uses This
Longevity researchers, mitochondrial biologists, metabolic scientists, exercise physiologists, and endocrinologists represent the primary research communities for MOTS-C. Biohackers and precision wellness practitioners following cutting-edge longevity science also closely reference MOTS-C literature.
Product Details
| Peptide | MOTS-C (Mitochondrial-Derived Peptide) |
| Content | 20mg per vial |
| Format | Lyophilized powder |
| BAC Water | Not included |
| Purity | ≥99% HPLC verified |
| Storage | 2–8°C refrigerated, away from light |
| Research Use | For laboratory and research purposes only |
Storage & Handling
Store lyophilized MOTS-C at 2–8°C away from light. Avoid freeze-thaw cycles. Once reconstituted, store at 2–8°C and use within 28–30 days.
Research & Scientific Interest
MOTS-C represents a paradigm shift in peptide science — the first demonstration that the mitochondrial genome encodes bioactive peptides that can regulate metabolism and aging at a systemic level. Pioneer research by Lee et al. (2015) showed that MOTS-C promotes insulin sensitivity, reduces obesity, and extends healthy metabolic function in aging mice. Subsequent work has established MOTS-C’s role in exercise physiology, osteoblast biology, and longevity signaling, positioning it as one of the most scientifically exciting peptides in the current longevity research landscape.
Frequently Asked Questions
MOTS-C is a 16-amino acid peptide encoded in the mitochondrial genome, studied for its remarkable effects on metabolic regulation via AMPK activation, insulin sensitivity, exercise performance, and longevity pathways.
MOTS-C is the first known mitochondria-encoded peptide to act as a systemic hormone. It translocates from mitochondria to the nucleus during cellular stress, directly regulating gene expression for metabolic adaptation — a mechanism unique among research peptides.
MOTS-C inhibits the folate cycle in the methionine metabolism pathway, leading to accumulation of AICAR — a potent endogenous AMPK activator. This indirect AMPK activation enhances cellular energy sensing and metabolic flexibility.
Yes. Research shows circulating MOTS-C levels increase during physical exercise. Studies suggest MOTS-C may function as an “exercise hormone,” mediating some of the metabolic benefits of physical activity through AMPK and related pathways.
Store lyophilized at 2–8°C away from light. Once reconstituted, refrigerate and use within 28–30 days.
No. Strictly for laboratory and research purposes only.
Yes. H&J Pharma offers same-day shipping with next-day delivery across Vietnam.
Research References
- Lee C, et al. “The mitochondrial-derived peptide MOTS-C promotes metabolic homeostasis.” Cell Metabolism. 2015. PubMed
- Reynolds JC, et al. “MOTS-C is an exercise-induced mitochondrial-encoded regulator.” Nature Communications. 2021. PubMed
- Kim SJ, et al. “MOTS-C improves mitochondrial function and insulin sensitivity.” Cell Reports. 2021.
- Zarse K, Ristow M. “A mitochondrially encoded hormone ameliorates obesity.” Cell Metabolism. 2015.
- Lu H, et al. “MOTS-C ameliorates cardiac dysfunction in type 2 diabetes.” Cardiovascular Research. 2019.
- Ming W, et al. “MOTS-C preserves mitochondrial function and prevents skeletal muscle atrophy.” Aging. 2020.
- Ramanjaneya M, et al. “MOTS-C is a mitochondrial-encoded regulator of the nuclear genome.” Diabetes. 2019.
- Kim KH, et al. “Mitochondrial MOTS-C regulates osteoclastogenesis.” Cell Metabolism. 2021.
- Lee C, Bhuta S, Mehta HH. “The coordination of mitochondrial and nuclear genomes.” Antioxidants & Redox Signaling. 2020.
- Cobb LJ, et al. “Naturally occurring mitochondrial-derived peptides are age-dependent regulators.” Communications Biology. 2016.
Lifestyle & Wellness Context
MOTS-C represents the frontier of longevity science — a mitochondria-derived peptide that bridges cellular energy biology and systemic metabolic health. H&J Pharma supplies MOTS-C 20mg at research grade with HPLC-verified purity and same-day shipping across Vietnam.
Related Wellness Research Areas
Research communities studying mitochondrial biology, AMPK signaling, longevity science, exercise physiology, insulin sensitivity, and metabolic health will find MOTS-C among the most exciting peptides in current longevity research.
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