SLU-PP-332 5mg — ERR Pan-Agonist & Exercise Mimetic Research Compound
SLU-PP-332 represents one of the most exciting developments in metabolic and exercise biology research. Developed at Washington University School of Medicine, SLU-PP-332 is a potent pan-agonist of estrogen-related receptors (ERRα, ERRβ, ERRγ) — nuclear receptors that regulate mitochondrial biogenesis, fatty acid oxidation, and oxidative metabolism. It is studied as a potential “exercise mimetic” — activating some of the same molecular pathways triggered by physical exercise.
Product Overview
Estrogen-related receptors (ERRs) are orphan nuclear receptors acting as master regulators of mitochondrial function and energy metabolism. ERRα and ERRγ activate gene expression governing oxidative phosphorylation, fatty acid β-oxidation, and mitochondrial biogenesis — the same pathways upregulated by endurance exercise through PGC-1α signaling. SLU-PP-332’s pan-ERR agonism activates these pathways pharmacologically.
Key Benefits
- Mitochondrial biogenesis — stimulates new mitochondria formation in muscle and cardiac tissue
- Aerobic capacity enhancement — preclinical studies show significant endurance improvements
- Fatty acid oxidation — promotes fat as preferred cellular fuel source
- Exercise mimetic properties — activates exercise-like metabolic pathways
- Heart failure research — cardiac exercise tolerance improvements in animal models
- Metabolic flexibility — improves cellular energy substrate switching
- Anti-obesity potential — studied in metabolic syndrome models
- Longevity pathway activation — ERR/PGC-1α signaling linked to lifespan research
Popular Use Cases
SLU-PP-332 research focuses on exercise physiology, cardiovascular metabolism, mitochondrial biology, and metabolic syndrome. Its exercise mimetic potential makes it relevant for researchers studying metabolic diseases where physical exercise is limited.
Who Commonly Uses This
Exercise physiologists, cardiovascular researchers, metabolic biologists, mitochondrial scientists, and longevity researchers are the primary communities. Biohackers interested in next-generation metabolic optimization research also follow SLU-PP-332 closely.
Product Details
| Compound | SLU-PP-332 (ERR pan-agonist) |
| Content | 5mg per vial |
| Format | Lyophilized powder |
| BAC Water | Not included |
| Purity | ≥99% HPLC verified |
| Storage | 2–8°C, away from light |
| Research Use | For laboratory and research purposes only |
Storage & Handling
Store at 2–8°C away from light. Once reconstituted, refrigerate and use within 28 days.
Research & Scientific Interest
Preclinical studies demonstrated that SLU-PP-332-treated mice ran significantly farther and longer than controls without additional training — suggesting genuine exercise-mimetic capacity. The compound’s simultaneous activation of ERRα, ERRβ, and ERRγ provides comprehensive activation of the exercise response transcriptome.
Frequently Asked Questions
A potent pan-agonist of estrogen-related receptors (ERRα, ERRβ, ERRγ) developed at Washington University. Acts as an exercise mimetic by activating mitochondrial biogenesis and fatty acid oxidation.
Orphan nuclear receptors that regulate mitochondrial function, oxidative phosphorylation, and fatty acid oxidation — the same pathways activated by endurance exercise via PGC-1α.
Treated mice showed significantly improved running endurance versus controls without additional training, demonstrating genuine exercise-mimetic capacity.
No. It acts on ERRs — orphan nuclear receptors unrelated to androgen or estrogen receptors, with no androgenic or estrogenic activity.
Store at 2–8°C away from light. Use within 28 days of reconstitution.
No. Strictly for laboratory and research purposes only.
Yes. H&J Pharma offers same-day shipping with next-day delivery across Vietnam.
Research References
- Dufour CR, et al. “Genome-wide orchestration by ERRα and ERRγ.” Cell Metabolism. 2007. PubMed
- Giguere V. “Transcriptional control of energy homeostasis by ERR.” Endocrine Reviews. 2008. PubMed
- Alaynick WA, et al. “ERRγ and the transition to oxidative metabolism.” Cell Metabolism. 2007. PubMed
- Schreiber SN, et al. “ERRα mediates exercise-induced mitochondrial biogenesis.” PNAS. 2004. PubMed
- Murray J, et al. “Targeting ERRα increases mitochondrial biogenesis.” Molecular and Cellular Biology. 2013. PubMed
- Audet-Walsh E, Giguere V. “ERRα and ERRγ universes.” Current Opinion Cell Biology. 2015.
- Watt MJ, et al. “PGC-1α stimulates fatty acid oxidation.” Journal of Physiology. 2004.
- Misra J, et al. “ERRs in T cell immunity.” Immunity. 2018.
- Lee C, et al. “MOTS-C and mitochondrial metabolism.” Cell Metabolism. 2015. PubMed
- Reynolds JC, et al. “MOTS-C is an exercise-induced regulator.” Nature Communications. 2021. PubMed
Lifestyle & Wellness Context
SLU-PP-332 represents the frontier of exercise biology research. H&J Pharma supplies SLU-PP-332 5mg at research grade with same-day shipping across Vietnam.
Related Wellness Research Areas
Communities studying exercise biology, mitochondrial biogenesis, metabolic flexibility, cardiac performance, obesity pharmacology, and longevity pathways will find SLU-PP-332 among the most exciting research compounds today.
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